In the call for articles for this special issue on girls’ health, we highlighted that “[g]irls’ health is an ongoing and evolving issue with ties that go beyond medical analyses to include a wide array of social, educational, political, and environmental discourses (among others!).” Th at a number of different perspectives might contribute to or strengthen the interdisciplinary focus of an issue as crucial as girls’ health was important to me as guest editor. Th is issue demonstrates that the relationship of girlhood to health—sexual health, in particular—is of critical concern to us all. It is an area full of challenges and barriers, most of them, as is evident in this issue, understood and often expressed by girls themselves. The articles presented here point to the many perspectives from which to approach this topic. Girls’ sexual health is linked to an array of intersecting issues including the pedagogical influences of popular romance literature; the ways in which girls use blogs to construct counter narratives about their sexual identity; how girls’ increased inclusion in citizenship discourses can increase their capacity to address sexual objectification; what girls do to negotiate power within their heterosexual relationships; how barriers to water access in Africa can lead to the awareness of the risks—which range from being perceived to be promiscuous to being raped—that young women face; as well as how the (mis)management of menstruation can affect girls’ education. This issue points to the global and local specifics of sexual health, and to health more generally. Th e concerns discussed here are geographically wide-ranging: Cameroon, Lesotho, Australia, the United States, and Canada provide the settings—some urban and others rural. Th e authors present a wide range of methodologies from which they explore girls’ health: literary analysis; autoethnography; and participatory methods such as digital storytelling, mediamaking, listening to what young people have to say in various research paradigms, blogging, and photovoice.