This article, conceived on an open-process approach, explains the Italian rule of law’s model promoted by Italy in multilateral and bilateral fora. The rule of law aims to counter the abuse of power by the authorities and to build a new legally oriented environment in a multilevel order. (The rule by law, however, may be used to oppress or discriminate against people and to avoid accountability under the guise of formality, legality, and legitimacy.) Furthermore, the rule of law is instrumentally valuable to economic sustainable growth in delivering concrete development. The Italian achievements are demonstrated by the experiences acquired in G20 anti-corruption initiatives that vouch for Italy’s legitimacy and credibility on priority areas related to the struggle against global crime, drugs, money laundering, and terrorism. Moreover, Italian juridical diplomacy for promoting the rule of law at the multilateral level is framed according to the guidelines of sustainable development and the protection of human rights.