This introductory article lays out the objectives for this special issue of Migration and Society. In focusing on the stakes of sanctuary, both this introduction and the special issue concentrate on the ways sanctuary is inspired by, connected to, and symbolic of larger political and social processes. To see what is at stake, we outline some of the myriad possible meanings of sanctuary and examine the justifications given by the actors who offer and take sanctuary including notions of justice, solidarity, charity, and resistance. In highlighting what is at stake in specific acts and practices of sanctuary, we explore the benefits of pursuing a multidisciplinary examination of sanctuary, such as the one offered by the articles collected in this special issue.