This article identifies what Sir Edmund Leach once called 'amongitis' as one of socio-cultural anthropology's major problems that make interdisciplinary dialogues on evidence-based epistemological topics difficult. Topics of wider and larger scale, however, can and should be addressed if anthropology brings out more fully its implicit epistemological strength of a dialogical relationship between objectivism and subjectivism. The current conditions of a globalizing world actually transform this possibility into a necessity. In order to face this need, a new realism is proposed that is capable of dealing with the conditions and challenges of a second modernity. Two ranges of epistemological sources are suggested that may inform such a new realism. One range is based in the traditions of Western philosophy, while the other is rooted outside the secularized or theological legacies of monotheism.