This essay examines the trajectories of skilled labor migrants within a global South-North migration matrix using an interdisciplinary framework. Focusing on Nigeria's huge brain drain phenomenon, the essay draws from the limited available data on the field, interpreting those data through theoretical perspectives from postcolonial studies, Marxism, cultural studies, and human geography. The study spotlights the example of the United States of America as a receptacle of skilled migrants and raises questions of social justice along the North-South divide. The research demonstrates that contrary to the dominant image promoted by some elements in the Western media of migrants as irritants or criminals who disturb well-cultivated, advanced World economies and social spaces, 1 those nations benefit highly from Africa's (and other migrant countries') labor diasporas, especially the highly skilled professionals.