The Anthropocene refers to the planetary scale of anthropogenic influences on the composition and function of Earth ecosystems and life forms. Socio-political and geographic responses frame the uneven topographies of climate change, while efforts to adapt and mitigate its impact extend across social and natural sciences. This review of anthropology's evolving engagement with the Anthropocene contemplates multifarious approaches to research. The emergence of multispecies ethnographic research highlights entanglements of humans with other life forms. New ontological considerations are reflected in Kohn's “Anthropology of Life,” ethnographic research that moves beyond an isolated focus on the human to consider other life processes and entities as research participants. Examples of critical engagement discussed include anthropology beyond disciplinary borders, queries writing in the Anthropocene, and anthropology of climate change. We demonstrate the diverse positions of anthropologists within this juncture in relation to our central trope of entanglements threaded through our discussion in this review.