This article offers a synthetic overview of the major opportunities and impasses of an emergent anthropology of experts and expertise. In the wake of the boom in anthropological science and technology studies since the 1980s, the anthropology of experts has become one of the most vibrant and promising enterprises in social-cultural anthropology today. And, yet, I argue that the theorisation and ethnography of experts and cultures of expertise remains underdeveloped in some crucial respects. The body of the article defines expertise as a relation of epistemic jurisdiction and explores the sociological and epistemological dilemmas emerging from research, that poises one expert (the anthropologist) in the situation of trying to absorb another regime of expertise into his/her own. With due appreciation for what the anthropology of experts has achieved thus far, I close with a manifesto designed to prompt a reassessment of where this research enterprise should go from here. I urge that we treat experts not solely as rational(ist) creatures of expertise but rather as desiring, relating, doubting, anxious, contentious, affective—in other words as human-subjects.