The current prevention policy continues to be reactive. It is even negative and demotivating. This atmosphere is destroying the working conditions we need in our new social-economic environment. Quality of work has become top of the agenda together with creativity, personal development and involvement. The human being is transformed from a potential source of disturbance into an essential success factor. A new approach to prevention policy is imposing itself in this context. Caring for safety, health and well-being of the employees at the same time means caring for the well-being and the future of the organization. The great challenge now becomes the development of the human potential. In that perspective a real proactive prevention policy is needed. Proactivity implies prevention but goes much further. Real proactivity refers to the dreams and positive objectives people wish to see realised. Well-being, participation and empowerment of all participants are important targets while the expected implications for culture are commitment, trust and open communication. This approach is very close to the conditional factors of social quality as described in the report of the European Foundation on the European Network Indicators of Social Quality.