This article addresses the anthropomorphization and interpellative experience of cars and trucks, in order to meet future mobility challenges. Autonomous vehicles offer an emancipatory opportunity within a wider movement of degendering and regendering motor vehicles. We argue that autonomous vehicles can challenge the foundations of a gendered economy founded on masculinity, speed, pleasure, and embodiment. Rather than thinking in terms of a process of demasculinization, this article anticipates a regendering and resegregation through which certain forms of masculine gendered economies of pleasure will lose ground and others will gain. A core question in this article asks who will be in the driver’s seat of future systems of automobility as the control of the vehicle is gradually being transferred from the driver to digital control systems and intelligent roads.