Travel is a special form of human mobility that is subject to different historical conditions and one that, deliberately or not, always entails knowledge acquisition and knowledge transfer. Travel facilitates the encounter with peoples, ideas, and material artifacts. In the age of Enlightenment, the nexus between travel and knowledge gained a new intensity, as the movement beyond the known turned into a specific scientific project with manifestations in theoretical reflection as well as literary practice. In the special section on Travel Writing and Knowledge Transfer contributors from the fields of Literary and Travel Studies investigate how human mobility gains epistemic significance in the exploration of nature and foreign cultures. The articles focus on conditions and forms of knowledge production while traveling (itinerant knowledge). They analyze how observations, experiences, and reflections made on the move are molded and transformed in fiction and nonfiction, and they discuss the impact on European cultural and intellectual horizons.