In this special issue of Anthropology in Action, applied anthropology colleagues from Durham University—one of the largest anthropology departments in the UK—come together to feature some of their recent research. Anthropology at Durham University is well known for its applied strain. And here, guest editor Paul Sillitoe, Professor of Anthropology at Durham, showcases some of the indigenous knowledge (IK) research projects emanating from Durham as part of their Anthropology in Development programme.