Our present understanding of innovation is closely linked to science and research on the one hand and economy and industry on the other. It has not always been so. Back in the sixteenth and seventeenth centuries, the concept was mainly used in religious and political discourses. In these contexts, actors used it in a pejorative sense. Innovation, imagined as a radical transformation, was considered a peril to the established social order. Such was natural philosophers’ understanding. Th is article documents Francis Bacon’s work as an eminent example of such a representation. To Bacon, natural philosophy and innovation are two distinct spheres of activity. It is documented that Bacon’s uses of the concept of innovation are found mainly in political, legal, and moral writings, not natural philosophy, because to Bacon and all others of his time, innovation is political.