Wheat is one of the world’s most widely grown, traded, and consumed crops. This article reviews the interdisciplinary literature on human-wheat interactions, tracing how various actors engage with wheat up until its point of consumption. I look first at wheat as a seed, examining efforts to transform wheat over time through farmer selection and scientific breeding, and the emergence of high-yielding wheat, hybrid wheat, and genetically modified wheat. Second, I look at wheat as a plant and what it means to farm wheat. I highlight two key dimensions of farmer-wheat interactions—farmers’ choice of variety and their management of risk. Finally, I look at wheat as a grain and the practices of transportation, sorting, and trade that mediate flows of harvested grain from field to market. Through reviewing these three areas of literature, the article reveals the social worlds that both shape and are shaped by this globally significant crop.