The rate of depletion of plants and animal species in Ghana has assumed an alarming dimension, and the government is finding it difficult to control the process. Several factors account for this. A major one is the neglect of the traditional ecological knowledge prevalent in the culture of Ghana. Sasa is the Akan word for the spirit believed to be found in some plants and animals. This paper examines the role of sasa in flora and fauna conservation in Ghana. Traditional Ghanaians have a strong belief that some plants and animals have special spirits, which when cut (as in the case with plants) or killed (animals) can bring serious harm to the person. Thus, such plants and animals are not eliminated. This paper argues that sasa as an Akan indigenous conservation tool can complement the modern means of nature conservation in Ghana.