Gluckman and the Manchester School pioneered approaches in anthropology that are now commonplace. But they were interested in achieving generalizations of both a local and more global kind. Their central methodology was that of situational analysis and extended-case analysis, which are examined here as attempts to make anthropology, via its ethnographic field method, a scientific discipline that opened out to novel ideas and theories concerning the human condition. This essay critically assesses the thinking that underpinned the methodology of situational analysis and suggests some areas of redirection. The overall idea is to impart some sense of the spirit that motivated various aspects of the Manchester innovation, especially the politics that gave it some coherence, and the wider importance of its directions that are occasionally overlooked in reflections on the history of social anthropology.